It stands in the locality of Grompa, once an integral part of the architectural complex known as Villa Grompo, also called "Il Paradiso".
It was the nobleman Ubertino Grompo who wanted the construction of the small church, completed by his son Rolando, and dedicated to the Blessed Virgin and Blessed Rantua.
Following the flooding of the Fossa Lovara (now Santa Caterina d'Este), the oratory fell into ruin. It was rebuilt and consecrated in the early 1600s, still under the care of the Grompo family, who had Mass celebrated there, for a fee, on holy days and the day of commemoration of the dead.
Towards the end of the 1400s, the oratory, under the patronage of the noble Grompo family, was in complete ruin, as confirmed by the pastoral visit of Bishop Callisto de Amadeis, dated October 27, 1536.
In the oratory, which remained under the patronage of the Grompo family until the end of the 1700s, the sacred relics of St. Emilio the martyr were venerated, equipped with the seal and letters patent from the diocesan curia.
In 1810, the noble Giovanelli family took over the properties of the Grompo family, and in 1930, Cavalier Cesare Longhi from Milan.
In 1989, Gaetano, Marco, and Davide Dondena, who took over the property, donated the building known as "Oratorio di Santa Rantua" to the municipality of Villa Estense.
In the following years, the oratory underwent a conservative restoration.
The oratory today features a façade inspired by classicism, framed by pilasters with Tuscan capitals and topped by a triangular pediment. Under the tympanum, there is a beautiful frieze, in classical style, adorned with triglyphs alternating with metopes.