Built by Cardinal Francesco Pisani, Bishop of Padua, at the beginning of the 1500s, during the same period when the prelate commissioned Palladio to design the Palazzo di Montagnana and the small palace of Monselice, which he made his residence of authority over the landholdings in the mainland. The Villa remained property of the Pisani family of Santo Stefano, the same family that built Villa Pisani di Stra in the 1700s, until 1900, when the last Countess Pisani, Evelina van Millingen Pisani, passed away. After a brief period of ownership by the Bentivoglio Mocenigo family, the residence passed to the Bolognesi Scalabrin family.
The rooms of the Villa are frescoed by the most important painters of the time, such as Paolo Veronese, Gianbattista Zelotti, and Dario Varotari, as well as the Flemish painter Ludovico Toeput, known as Pozzoserrato. The furnishings are original period pieces, and some 19th-century stuccos decorate the music room.
A vast and splendid Italian garden, with Islamic contaminations, surrounds the Palace, followed by a very large romantic park in the 19th-century English style. This work was commissioned by Countess Evelina van Millingen Pisani, wife of Almorò Pisani, who in the 1800s decided to replace the citrus grove with an Hortus Floridus rich in all sorts of bulb flowers, antique roses, and many species of trees, including non-native ones.
In the garden and park, one can find and admire statues by Besarel, fountains, ponds, a neo-Gothic chapel by Selvatico, a theater, a well, an ice house, barchesse, and stables.
